APA Handbook of Depression Volume 1: Classification, Co-Occurring Conditions, and Etiological Processes; Volume 2: Minoritized Populations, Lifespan Development, Assessment, and Treatment

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Pub. Date: 2025-11-25
Publisher(s): American Psychological Association
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Summary

This comprehensive two-volume handbook provides an authoritative, robust examination of current information on depression.
 
Depression is a leading cause of disability, a major contributor to global disease burden, and one of the most commonly presenting problems in mental health and primary care settings. Its pervasive impact on individuals, families, and communities underscores the urgency of advancing understanding and treatment of this complex mental health condition. The APA Handbook of Depression reflects the critical need for a comprehensive resource that highlights advancements, presents up-to-date knowledge, and provides mental health professionals with a robust foundation for clinical practice, research, and education. The 75 chapters in the handbook represent the collective efforts of leaders in the field, spanning diverse disciplines and perspectives, and reflecting a rich tapestry of expertise within depression research and practice. Chapter contributors synthesized the latest research findings and clinical insights into a compendium that contextualizes the breadth and depth of basic and applied research on depression within diverse populations and developmental periods, while also identifying critical directions for future research.
 
Volume 1 contains four parts focusing on classification, epidemiology, co-occurring conditions, and etiological processes of depression. Part 1 delves into the historical context of depression, diagnostic classification, epidemiological trends, and the burden of co-occurring conditions such as anxiety disorders, substance use disorders, and trauma-related disorders, among others. Part 2 explores multiple biological contributors to depression, from molecular genetics to brain structure and function to psychophysiology and neuroimmune interactions. Part 2 further delves into behavioral genetics, animal models of depression, and the role of sleep and circadian rhythms in depression. Part 3 examines individual differences and psychological processes, including temperament, attachment, stress reactivity, self-regulation, and reward processing. Part 3 also considers learning and cognition in depression, including attention, interpretation, cognitive control, and memory. Finally, Part 4 covers social and cultural processes in depression, including interpersonal relationships, community, and cultural processes. Part 4 also addresses depression-related stigma and the increasing relevance of technology to depression. In Volume 2, the focus shifts to depression in historically marginalized  populations, depression across the lifespan, and assessment, prevention, and treatment of depression. Part 1 highlights the unique challenges faced by diverse populations and minoritized groups. Part 2 addresses depression across different developmental stages, from early childhood to late life depression, and depression in the peripartum period. Part 3 covers ethical issues in research and practice with depression and also focuses on assessment approaches in relation to depression that include traditional and more modern methods. Finally, Part 4 provides a comprehensive review of prevention and treatment approaches, including culturally sensitive approaches, behavioral and psychological treatments, and pharmacological and neuromodulatory treatments. Part 4 additionally covers depression in primary care settings and the burgeoning literature on technology-facilitated and precision treatment approaches.
 
Written in clear and accessible language, the chapters are tailored to meet the needs of a broad spectrum within the mental health community. This includes researchers, practitioners, scholars, and students in psychology and related fields such as psychiatry and social work. Whether seeking to stay informed about cutting-edge research, enhance clinical practice, or further academic training, this invaluable resource offers knowledge to support individuals at all stages of their professional development.

Author Biography

Jeremy W. Pettit, PhD, is a professor of psychology and psychiatry at Florida International University, where he is executive director of the Center for Children and Families. His research aims to advance understanding of the etiology and maintenance of depression, anxiety, and suicidal behaviors, and facilitate more effective treatments. That research has produced more than 175 journal articles chapters, and Dr. Pettit has authored award-winning books on depression. His efforts in preventing suicidal behaviors in young people were recognized by the American Association of Suicidology. He has served as executive editor of Behavioral Medicine and associate editor of International Journal of Cognitive Therapy and Journal of Social and Clinical Psychology.

Thomas M. Olino, PhD, is a licensed clinical psychologist and professor of psychology and neuroscience at Temple University. He is an associate editor for the journal Training and Education in Professional Psychology and served as an associate editor for Assessment and academic editor for PlosOne. Dr. Olino has authored more than 200 peer-reviewed articles, and his research has been supported by the Brain and Behavior Research Foundation and National Institute of Mental Health. The focus of his work is on developmental psychopathology, relying on high-risk offspring designs to better understand developmental trajectories of risk, reflected by temperamental, emotional, and neurobiological processes.

Rhonda C. Boyd, PhD, is an associate professor in the Department of Child and Adolescent Psychiatry and Behavioral Sciences at the Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania Perelman School of Medicine. Additionally, she is a researcher at CHOP PolicyLab and practices as a licensed psychologist. She has served as a principal investigator and coinvestigator on multiple federal grants and as consulting editor of the Journal of Clinical Child and Adolescent Psychology, among other positions. Visit Dr. Boyd’s faculty page here.

Brian C. Chu, PhD, is professor and past department chair of the Department of Clinical Psychology in the Graduate School of Applied and Professional Psychology at Rutgers University, and founder/director of the Youth Anxiety and Depression Clinic. Dr. Chu’s work focuses on anxiety and mood problems in children and adolescents. He has received grant funding to develop and evaluate behavioral interventions, understand the impact of internalizing problems on families, and extend services to underserved communities. He is an author an editor and a fellow of the Association for Behavioral and Cognitive Therapies.

Elizabeth P. Hayden, PhD, is a professor of psychology and principal investigator of the Brain and Mind Institute at the University of Western Ontario, where she heads the Lifespan study of Emotion And Personality (LEAP) Lab.  Dr. Hayden’s research takes a developmental psychopathology approach to understanding the biological and contextual pathways to mood dysregulation. She has authored over a hundred peer-reviewed articles and coauthored the Oxford Handbook of Stress and Mental Health (Oxford University Press), and she serves as an associate editor for the journal Psychological Assessment

Diego A. Pizzagalli, PhD, serves as founding director of the Center for Depression, Anxiety and Stress Research; the director of the McLean Imaging Center; and the director of research for the Division of Depression and Anxiety at McLean Hospital. He is a professor of psychiatry at Harvard Medical School, and the center director for Silvio O. Conte Center for Basic Translational Mental Health Research. In 2024, he will become the founding director of the Noel Drury, MD Institute for Translational Depression Discoveries at the University of California, Irvine, and a visiting professor at Oxford University. His research aims improve understanding of the psychological, environmental, and neurobiological factors associated with mood disorders, particularly major depression. Dr. Pizzagalli has published over 360 papers and chapters and serves on the editorial boards of 13 journals.




 

Table of Contents

Volume 1. Classification, Co-Occurring Conditions, and Etiological Processes

Contents
 
Editorial Board
About the Editors-in-Chief
About the Associate Editors
Contributors
A Note from the Publisher
Introduction
  
Part I. Classification, Epidemiology, and Commonly Co-Occurring Conditions
 
Chapter 1. Historical Perspectives on Depression     
Allan V. Horwitz, Lorenzo Lorenzo-Luaces, and Jerome C. Wakefield
 
Chapter 2. Diagnosis and Classification of Depressive Disorders
Daniel N. Klein
 
Chapter 3. The Public Health of Depression 
Victoria K. Ngo, Catherine Dinh-Le, and Marina Weiss
 
Chapter 4. Anxiety Disorders and Co-occurrence With Depression 
Cecilia A. Essau, Hakan Sahin, and Trudy Au Ai Lynn
 
Chapter 5. Depression and Comorbid Substance Use           
Sylia Wilson and Kayla M. Nelson
 
Chapter 6. Depression and Co-Occurring Trauma-Related Disorders          
Sara M. Witcraft, Lauren M. Henry, Shannon E. Cusack, and Daniel F. Gros
 
Chapter 7. Depression Across the Life Course, Identities, and Cultures      
Catherine K. Ettman, Sasha Rudenstine, and Sandro Galea
 
Chapter 8. Depression and Co-Occurring Eating Disorders 
Jennifer E. Wildes, Angeline R. Bottera, and Elizabeth Dougherty
 
Chapter 9. Co-Occurring ADHD, Disruptive Behavior Disorders, and Depression 
Andrea Chronis-Tuscano, Lauren E. Oddo, Karen T.G. Schwartz, and Michael C. Meinzer
 
Chapter 10. Depression and Other Medical Conditions        
Jerry Suls and Elizabeth A. Vrany
 
Chapter 11. Suicide and Depression: Epidemiology, Theory, Assessment, and Treatment 
Richard T. Liu, Marin M. Kautz, Rachel F. L. Walsh, Olivia H. Pollak, Matthew G. Clayton, and Auburn R. Stephenson
 
Chapter 12. Depression and Co-Occurring Non-Suicidal Self-Injury (NSSI)          
Evan M. Kleiman, John (Kai) Kellerman, Annabelle Mournet, and Ellen Wittler
 
Chapter 13. Bereavement Related Depression and Prolonged Grief Disorder         
Evgenia Milman and Robert A. Neimeyer
 
Part II. Genetic and Biological Processes
 
Chapter 14. Behavioral Genetics of Depression: Leveraging Family-based Studies to Understand the Etiology of Depression 
Sara A. Norton, Erin Bondy, and Ryan Bogdan
 
Chapter 15. Molecular Genetics and Epigenetics in Depression       
Darina Czamara and Elisabeth B. Binder
 
Chapter 16. Animal Models for Depression Research          
Scott J. Russo and Peter H. Rudebeck
 
Chapter 17. Neurotransmitters and Neuropeptides   
Gustavo C. Medeiros, Todd D. Gould, Isabella Demo, Fernando S. Goes, and Carlos A. Zarate Jr.
 
Chapter 18. Psychophysiology and Depression         
Anna Weinberg, Aislinn Sandre, Lidia Panier, Clara Freeman, Simon Morand-Beaulieu, and Corinne Sejourne
 
Chapter 19. The Neurobiological and Molecular Underpinnings of Depressive Phenotypes           
Eric M. Parise and Eric J. Nestler
 
Chapter 20. Psychoneuroimmunology of Depression
George M. Slavich, Valeria Mondelli, and Daniel P. Moriarity
 
Chapter 21. Sleep and Circadian Rhythms in Depression     
Melynda Casement and Xi Yang
 
Part III. Psychological Processes
 
Chapter 22. Temperament, Personality, and Depression       
Yuliya Kotelnikova, Kasey J. Stanton, and Elizabeth P. Hayden
 
Chapter 23. Attachment Representations and Depression     
Elaine Scharfe
 
Chapter 24. Stress and Diathesis-stress Models        
Kate L. Harkness and Jeremy G. Stewart
 
Chapter 25. Self-Regulation, Emotion Regulation, and Depression: An Integrative Review and a Developmental Perspective
Carolina Daffre, Ann B. Brewster, and Timothy J. Strauman
 
Chapter 26. Reward Processing in Depression
Argyris Stringaris and Vasileia Kotoula
 
Chapter 27. Behavior and Learning in Depression    
Vanessa Brown
 
Chapter 28. Attention and Interpretation in Depression        
Rebecca B. Price and Mary L. Woody
 
Chapter 29. Executive and Cognitive Control in Depression
Jutta Joormann and Ashleigh V. Rutherford
 
Chapter 30. Memory in Depression
Eni S. Becker and Janna N. Vrijsen
 
Part IV. Social and Cultural Processes
 
Chapter 31. Transmission of Depression Risk Across Two and Three Generations
Sherryl H. Goodman
 
Chapter 32. Romantic Relationships and Depression
Tamara Luginbuehl, Daphne Y. Liu, John V. Miller, and Joanne Davila
 
Chapter 33. Peer Relationships and Depression        
Matteo Giletta and Karen D. Rudolph
 
Chapter 34. Depression and the Roles of Neighborhood and Community   
Sharon F. Lambert and Andrew A. Gepty
 
Chapter 35. Depression in the Context of Race, Ethnicity, and Culture       
Oswaldo Moreno, Tamara Nelson, Nestor Noyola, and Camila Tirado
 
Chapter 36. Stigma and Depression   
Lindsay Sheehan, Madeline Oppenheim, and Patrick Corrigan
 
Chapter 37. Technology and Depression       
Jessica L. Hamilton, Saskia L. Jorgensen, Simone I. Boyd, and Melissa J. Dreier
 
Index


Volume 2. Minoritized Populations, Lifespan Development, Assessment, and Treatment
 
Contents
 
Editorial Board
Contributors
 
Part I. Depression in Minoritized Populations
 
Chapter 1. Depression in Asian Americans   
Wei-Chin Hwang
 
Chapter 2. Depression Among Black and African American Individuals    
Alvin Thomas, Adrian Gale, and Ed-Dee Williams
 
Chapter 3. Depression in Latinx Individuals
Esteban V. Cardemil and Nicolás Alvarez-Frank
 
Chapter 4. Depression and Indigenous Peoples in the United States and Canada: Prevalence, Risk/Protective Factors, Interventions
Dennis C. Wendt, Mathilde Garneau, Hannah Fraser-Purdy, Nicole Augustine,
Caitlin Gilpin, Sherry H. Stewart, Christopher J. Mushquash, and Jacob A. Burack   
 
Chapter 5. Depression in Sexual and Gender Minority People         
Kirsty A. Clark, John E. Pachankis, and Steven A. Safren
 
Chapter 6. Considerations for Assessment and Treatment of Depression in the Disability Community     
Lauren R. Khazem, Emily M. Lund, and Kara B. Ayers
 
Chapter 7. Depression and Gender    
Janet Shibley Hyde and Rachel H. Salk
 
Chapter 8. Addressing Depression Disparities: The Potential of Intersectionality Theory and Praxis         
NiCole T. Buchanan and Lauren O. Wiklund
 
Part II. Depression Across the Lifespan
 
Chapter 9. Depression in Early Childhood   
Lea R. Dougherty, Leah K. Sorcher, Grace Messina, and Mina Hughes
 
Chapter 10. Depression in Childhood
Brandon E. Gibb, Elana S. Israel, and Pooja Shankar
 
Chapter 11. Major Depressive Disorder in Adolescence      
Randy P. Auerbach, David Pagliaccio, Paul Bloom, Rachel Cherner, Carter J. Funkhouser, and Jaclyn S. Kirshenbaum
 
Chapter 12. Depression in Later Life
Ann M. Steffen and Kelly Bergstrom
 
Chapter 13. Depression in the Peripartum Period     
Huynh-Nhu Le, Deepika Goyal, and Kantoniony M. Rabemananjara
 
Part III. Assessment
 
Chapter 14. Ethics of Research and Practice With Depression         
Matthew Rudorfer, Andrew Jones, and Galia Siegel
 
Chapter 15. Self-Reported Assessments of Depression        
Lorenzo Lorenzo-Luaces, Allison Peipert, and Robinson de Jesús-Romero
 
Chapter 16. Interviews and Clinician-Rated Measures of Depression          
R. Michael Bagby, Aqsa Zahid, and Sharlane C. L. Lau
 
Chapter 17. Behavioral and Ecological-Momentary Assessments    
Nicole R. Nugent, Charlene Collibee, Shaquanna Brown, and Michael F Armey
 
Chapter 18. Using Passively Collected Digital Phenotypes to Assess and Predict Depression        
Nicholas C. Jacobson, Jenny Y. Oh, Stephen M. Adjei, and Julia Shen
 
Chapter 19. Neuroimaging of Depression     
Conor Liston, Immanuel Elbau, and Benjamin Zebley
 
Chapter 20. Liquid Biomarkers of Depression          
Flurin Cathomas, Sara Costi, Orna Issler, Kenny L. Chan, Chris Kelly, Scott J. Russo, and James W. Murrough
 
Part IV. Prevention and Treatment
 
Chapter 21. Cultural Formulation and Culturally-Adapted Treatments for Depression       
Monnica Williams, Tahlia Harrison, and Joseph T. La Torre
 
Chapter 22. Prevention of Depression Across the Lifespan  
Judy Garber, V. Robin Weersing, and Pauline Goger
 
Chapter 23. Behavioral Treatments for Depression  
Jamie C. Kennedy, Sarah E. Baldwin, and W. Edward Craighead
 
Chapter 24. Cognitive Therapy for Depression: What We Got Right and What We Got Wrong    
Steven D. Hollon and Iony D. Ezawa
 
Chapter 25. Interpersonal Psychotherapy for Depression     
Laura Mufson, Jami F. Young, Laura J. Dietz, and Karen T. G. Schwartz
 
Chapter 26. Mindfulness-Based Interventions for Depression
Amanda L. Shamblaw and Zindel Segal
 
Chapter 27. Acceptance and Commitment Therapy for Depression 
Carter H. Davis, Emily M. Bowers, Michael E. Levin, and Michael P. Twohig
 
Chapter 28. Cognitive Bias Modification for Depression     
Christopher G. Beevers, Mary E. McNamara, Mackenzie Zisser, and Rachel L. Weisenburger
 
Chapter 29. Attachment-Based Family Therapy for Depression: Theory, Clinical Model, Research, and Future Directions       
Guy Diamond, Suzanne Levy, and Ashley King
 
Chapter 30. Psychodynamic Treatments of Depression        
Patrick Luyten and Peter Fonagy
 
Chapter 31. Pharmacotherapy for Depression           
Emine Rabia Ayvaci, Manish K. Jha, Taryn Mayes, and Madhukar H. Trivedi
 
Chapter 32. Neuromodulation for Unipolar Depression        
Donel M. Martin, Adriano H. Moffa, and Stevan Nikolin
 
Chapter 33. Complementary Health Approaches to Depression       
Jenn A. Leiferman, James F. Paulson, Chelsea Walker-Mao, and Jessica Walls
 
Chapter 34. Technology-facilitated Prevention and Treatment of Depression         
Mei Yi Ng, Jenny Guo, Jennifer Frederick, and Lindsey Cunningham
 
Chapter 35. The Unified Protocol: A Transdiagnostic Approach to the Diagnosis and Treatment of Depression
Todd J. Farchione, Daniella Spencer-Laitt, Laura J. Long, and Lauren S. Woodard
 
Chapter 36. Introduction to Augmented Intervention Approaches in the Treatment of Depression 
Beth D. Kennard, Rebecca Wildman, Kristin Wolfe, and Jessica Heerscap
 
Chapter 37. Intervention for Depression in Primary Care
Anne I. Roche, Olivia E. Bogucki, Nathaniel Lombardi, Jocelyn Lebow, and Craig N. Sawchuk
 
Chapter 38. Precision Mental Health Care for Depression    
Jaime Delgadillo and Wolfgang Lutz
 
Index

 

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