Evolution after Gene Duplication

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Edition: 1st
Format: Hardcover
Pub. Date: 2010-10-12
Publisher(s): Wiley-Blackwell
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Summary

Gene duplication has long been believed to have played a major role in the rise of biological novelty through evolution of new function and gene expression patterns. The first book to examine gene duplication across all levels of biological organization, Evolution after Gene Duplication presents a comprehensive picture of the mechanistic process by which gene duplication may have played a role in generating biodiversity. This up-to-date overview of theory and mathematical models along with practical examples is suitable for scientists across various levels of biology as well as instructors and graduate students.

Author Biography

Katharina Dittmar de la Cruz holds both a Ph.D. in Molecular Parisitology and Entomology and a doctorate in Veterinary Medicine, both from the University of Leipzig, Germany.?An expert in phylogenetics, molecular evolution, and bioinformatics, she has recently turned her attention toward examining the implications of evolutionary forces on drug design.?Dr. Dittmar is an Assistant Professor at the SUNY University at Buffalo.

David Liberles earned his Ph.D. in Chemistry at the California Institute of Technology working on the biochemsitry of nucleic acids.?Subsequently, he has developed significant expertise in bioinformatics, computational biology and functional genomics.?His broad experience includes a professorship at the Stockholm Bioinformatics Center and consultancies with Novo Nordisk and other private research and diagnostic companies.?Currently he is Vice-Director of the University of Wyoming Bioinformatics Center and Assistant Professor of Molecular Biology.

Table of Contents

Contributorsp. vii
Prefacep. xi
Understanding Gene Duplication Through Biochemistry and Population Geneticsp. 1
Functional Divergence of Duplicated Genesp. 23
Duplicate Retention After Small- and Large-Scale Duplicationsp. 31
Gene Dosage and Duplicationp. 57
Myths and Realities of Gene Duplicationp. 77
Evolution After and Before Gene Duplication?p. 105
Protein Products of Tandem Gene Duplication: A Structural Viewp. 133
Statistical Methods for Detecting Functional Divergence of Gene Familiesp. 163
Mapping Gene Gains and Losses Among Metazoan Full Genomes Using an Integrated Phylogenetic Frameworkp. 173
Reconciling Phylogenetic Treesp. 185
On the Energy and Material Cost of Gene Duplicationp. 207
Fate of a Duplicate in a Network Contextp. 215
Evolutionary and Functional Aspects of Genetic Redundancyp. 229
Phylogenomic Approach to the Evolutionary Dynamics of Gene Duplication in Birdsp. 253
Gene and Genome Duplications in Plantsp. 269
Whole Genome Duplications and the Radiation of Vertebratesp. 299
Indexp. 313
Table of Contents provided by Ingram. All Rights Reserved.

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